Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 7/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 7/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 7/20 | 0.38 |
| ▸ | F2 | P00734 | 6/20 | 0.38 |
| ▸ | PLG | P00747 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798709 | 0.82 | DPP7 (0.48) | KDM4EALDH1A1HTTGAAMAPT | |
| SCHEMBL3910177 | 0.78 | NR1H2 (0.49) | NR1H2KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL38657715 | 0.78 | TNF (0.41) | NR1H2TMEM97SIGMAR1TNF | |
| SCHEMBL8605349 | 0.76 | TMEM97 (0.49) | NR1H2KDM4EALDH1A1HTTGAA | |
| SCHEMBL8798786 | 0.76 | NR1H2 (0.49) | NR1H2KDM4EALDH1A1GABRA1GABRG2 | |
| SCHEMBL27593301 | 0.74 | NR1H2 (0.50) | NR1H2KDM4EALDH1A1GABRA1GABRG2 | |
| SCHEMBL218643 | 0.74 | NR1H2 (0.48) | NR1H2KDM4EALDH1A1MAPTHTR1A | |
| SCHEMBL30534578 | 0.74 | HRH3 (0.48) | NR1H2KDM4EALDH1A1GAAMAPT | |
| SCHEMBL1950813 | 0.74 | HRH3 (0.48) | NR1H2KDM4EALDH1A1GAAMAPT | |
| SCHEMBL1294235 | 0.73 | NR1H2 (0.58) | NR1H2KDM4EALDH1A1HTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5789595-A | ANTICOAGULANTS | TERUMO KABUSHIKI KAISHA (JP) | 1998-08-04 | — | — | US | disclosed |
| CN-1167485-A | Tetrahydroisoquinoline derivative and medicinal preparation containing the same | TERUMO CORP (JP) | 1997-12-10 | — | — | CN | disclosed |
| EP-0790247-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE AND MEDICINAL PREPARATION CONTAINING THE SAME | TERUMO KABUSHIKI KAISHA (JP) | 1997-08-20 | — | — | EP | disclosed |