SCHEMBL8798907

SCHEMBL8798907

Cc1cccc(Nc2cc(NC3CCNCC3)ncn2)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 3/20 0.52
TNNI3K Q59H18 2/20 0.50
ALDH1A1 P00352 2/20 0.48
HSD17B10 Q99714 2/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2C9 P11712 1/20 0.48
ALOX15 P16050 1/20 0.48
CYP2C19 P33261 1/20 0.48
MAPK1 P28482 3/20 0.45
SYK P43405 2/20 0.45
KCNH2 Q12809 2/20 0.45
MAPK3 P27361 1/20 0.45
AURKB Q96GD4 1/20 0.45
IRAK4 Q9NWZ3 2/20 0.45
HRH4 Q9H3N8 2/20 0.44
HRH3 Q9Y5N1 2/20 0.44
HRH2 P25021 1/20 0.44
MKNK1 Q9BUB5 1/20 0.43
MKNK2 Q9HBH9 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8798647 0.85 EGFR (0.55) EGFRTNNI3KALDH1A1HSD17B10MAPK1
SCHEMBL8798643 0.85 EGFR (0.55) EGFRTNNI3KALDH1A1HSD17B10MAPK1
SCHEMBL7856313 0.85 TNNI3K (0.49) EGFRTNNI3KALDH1A1HSD17B10CYP1A2
SCHEMBL8798960 0.84 EGFR (0.54) EGFRTNNI3KALDH1A1KDM4EL3MBTL1
SCHEMBL8799149 0.83 IRAK4 (0.50) EGFRTNNI3KCYP1A2CYP3A4CYP2C9
SCHEMBL8799084 0.83 IRAK4 (0.50) EGFRTNNI3KCYP1A2CYP3A4CYP2C9
SCHEMBL8801487 0.83 EGFR (0.50) EGFRTNNI3KALDH1A1KDM4EL3MBTL1
SCHEMBL8798922 0.82 EGFR (0.52) EGFRTNNI3KALDH1A1KCNH2IRAK4
SCHEMBL8799671 0.82 EGFR (0.49) EGFRTNNI3KALDH1A1KDM4EL3MBTL1
SCHEMBL8798928 0.82 EGFR (0.52) EGFRTNNI3KALDH1A1KCNH2IRAK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1047778-C Pyrimido [5-4-d] pyrimidines, drugs containing these compounds, their use and process for preparing them THOMAE GMBH DR K (DE) 1999-12-29 CN disclosed
EP-0779888-A1 PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM Dr. Karl Thomae GmbH (DE) 1997-06-25 EP disclosed
WO-1996007657-A1 PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM DR. KARL THOMAE GMBH (DE) 1996-03-14 WO disclosed