Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 17/20 | 0.48 |
| ▸ | LTB4R2 | Q9NPC1 | 11/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9118392 | 0.93 | LTB4R (0.54) | LTB4RLTB4R2CYP2C9 | |
| SCHEMBL8800004 | 0.93 | LTB4R (0.54) | LTB4RLTB4R2CYP2C9 | |
| SCHEMBL8802026 | 0.93 | LTB4R (0.54) | LTB4RLTB4R2CYP2C9 | |
| SCHEMBL8466646 | 0.93 | LTB4R (0.52) | LTB4RLTB4R2CYP2C9 | |
| SCHEMBL8799337 | 0.93 | LTB4R (0.54) | LTB4RLTB4R2CYP2C9 | |
| SCHEMBL8800165 | 0.93 | LTB4R (0.54) | LTB4RLTB4R2CYP2C9 | |
| SCHEMBL9118199 | 0.89 | LTB4R (0.48) | LTB4RLTB4R2CYP2C9 | |
| SCHEMBL9118536 | 0.87 | LTB4R (0.43) | LTB4RLTB4R2ALDH1A1 | |
| SCHEMBL8799461 | 0.86 | LTB4R (0.48) | LTB4RLTB4R2PPARDALDH1A1CYP2C9 | |
| SCHEMBL9119390 | 0.85 | LTB4R (0.46) | LTB4RLTB4R2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755381-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B 4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028386-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-10-26 | — | — | WO | disclosed |
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |