Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799804 | 1.00 | ACACB (0.51) | ACACBSIGMAR1MAPTKDM4EALDH1A1 | |
| SCHEMBL9086590 | 1.00 | ACACB (0.51) | ACACBSIGMAR1MAPTKDM4EALDH1A1 | |
| SCHEMBL8799241 | 0.92 | SIGMAR1 (0.51) | ACACBSIGMAR1GRM2F10 | |
| SCHEMBL8799320 | 0.92 | SIGMAR1 (0.51) | ACACBSIGMAR1GRM2F10 | |
| SCHEMBL9086619 | 0.92 | SIGMAR1 (0.51) | ACACBSIGMAR1GRM2F10 | |
| SCHEMBL8799146 | 0.89 | SIGMAR1 (0.48) | SIGMAR1MAPTGRM2F10SMN1; SMN2 | |
| SCHEMBL8798947 | 0.89 | SIGMAR1 (0.48) | SIGMAR1MAPTGRM2F10SMN1; SMN2 | |
| SCHEMBL8799565 | 0.89 | SIGMAR1 (0.48) | SIGMAR1MAPTGRM2F10SMN1; SMN2 | |
| SCHEMBL8799230 | 0.87 | SIGMAR1 (0.59) | SIGMAR1GRM2MCHR1 | |
| SCHEMBL8799808 | 0.87 | SIGMAR1 (0.57) | SIGMAR1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635505-B1 | 4-Aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GMBH (DE) | 1997-10-15 | — | — | EP | disclosed |
| US-5561145-A | 4-aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESHRANKTER HAFTUNG (DE) | 1996-10-01 | — | — | US | disclosed |
| EP-0635505-A1 | 4-Aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GmbH (DE) | 1995-01-25 | — | — | EP | disclosed |