Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 3/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CNR1 | P21554 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10676845 | 0.87 | MEN1 (0.51) | MEN1KMT2ATSHRESR1ESR2 | |
| SCHEMBL29562691 | 0.85 | ALDH1A1 (0.63) | MEN1KMT2ATSHRESR1ESR2 | |
| SCHEMBL10679786 | 0.84 | MEN1 (0.39) | MEN1KMT2ATSHRESR1ESR2 | |
| SCHEMBL10679881 | 0.84 | MEN1 (0.39) | MEN1KMT2ATSHRESR1ESR2 | |
| SCHEMBL8972857 | 0.83 | MEN1 (0.40) | MEN1KMT2ATSHRESR1ESR2 | |
| SCHEMBL9000114 | 0.83 | ALDH1A1 (0.39) | MEN1KMT2ATSHRMAPTSMN1; SMN2 | |
| SCHEMBL8973302 | 0.83 | POLB (0.38) | MEN1KMT2ATSHRMAPTHTT | |
| SCHEMBL10675527 | 0.82 | KMT2A (0.54) | MEN1KMT2ATSHRMAPTSMN1; SMN2 | |
| SCHEMBL10677381 | 0.82 | SMN1; SMN2 (0.44) | MEN1KMT2ATSHRMAPTSMN1; SMN2 | |
| SCHEMBL10681820 | 0.82 | CYP3A4 (0.53) | MEN1KMT2ATSHRMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4743611-A | TREATMENT OF DIABETIC COMPLICATIONS | AMERICAN HOME PRODUCTS CORP. (US) | 1988-05-10 | — | — | US | claimed |
| EP-0251784-A2 | Naphthalenylsulfonylimidazolidinediones and their thioxo analogs | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-01-07 | — | — | EP | claimed |
| JP-62201873-A | — | — | None | — | — | JP | disclosed |
| EP-0355827-B1 | Hydantoin derivatives | MOCHIDA PHARM CO LTD (JP) | 1997-01-02 | — | — | EP | disclosed |
| EP-0444546-B1 | Hydantoin derivatives for use as hypoglycemic and/or hypolipidemic agents | MOCHIDA PHARM CO LTD (JP) | 1996-09-11 | — | — | EP | disclosed |
| US-RE35279-E | ALDOSE REDUCTASE INHIBITORS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| US-5202339-A | Hypoglycemic, hypolipedemic agents | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1993-04-13 | — | — | US | disclosed |
| EP-0305947-B1 | HYDANTOIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS WELL AS THEIR USE | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-29 | — | — | EP | disclosed |
| WO-1991012803-A1 | HYDANTOIN DERIVATIVES FOR USE AS HYPOGLYCEMIC AND/OR HYPOLIPIDEMIC AGENTS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1991-09-05 | — | — | WO | disclosed |
| EP-0444546-A1 | Hydantoin derivatives for use as hypoglycemic and/or hypolipidemic agents | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1991-09-04 | — | — | EP | disclosed |
| US-5004751-A | Antidiabetic agents; aldoe reductase inhibitors | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1991-04-02 | — | — | US | disclosed |
| EP-0355827-A2 | Hydantoin derivatives | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1990-02-28 | — | — | EP | disclosed |
| WO-1989001934-A1 | HYDANTOIN DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1989-03-09 | — | — | WO | disclosed |
| US-4743611-A | TREATMENT OF DIABETIC COMPLICATIONS | AMERICAN HOME PRODUCTS CORP. (US) | 1988-05-10 | — | — | US | disclosed |
| US-4743611-A | TREATMENT OF DIABETIC COMPLICATIONS | AMERICAN HOME PRODUCTS CORP. (US) | 1988-05-10 | — | — | US | disclosed |
| US-4743611-A | TREATMENT OF DIABETIC COMPLICATIONS | AMERICAN HOME PRODUCTS CORP. (US) | 1988-05-10 | — | — | US | disclosed |
| EP-0251784-A2 | Naphthalenylsulfonylimidazolidinediones and their thioxo analogs | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-01-07 | — | — | EP | disclosed |
| EP-0251784-A2 | Naphthalenylsulfonylimidazolidinediones and their thioxo analogs | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-01-07 | — | — | EP | disclosed |
| EP-0251784-A2 | Naphthalenylsulfonylimidazolidinediones and their thioxo analogs | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-01-07 | — | — | EP | disclosed |
| JP-S62201873-A | HYDANTOIN DERIVATIVE AND ALDOSE REDUCTASE INHIBITOR CONTAINING SAID DERIVATIVE AS ACTIVE INGREDIENT | MOCHIDA PHARMACEUT CO LTD | 1987-09-05 | — | — | JP | disclosed |