Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.46 |
| ▸ | HTR7 | P34969 | 3/20 | 0.46 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8800905 | 0.95 | GRM2 (0.54) | GRM2MEN1MAPTMAPK1KMT2A | |
| SCHEMBL8801934 | 0.92 | GRM2 (0.59) | GRM2SIGMAR1HTR7 | |
| SCHEMBL8801826 | 0.91 | SIGMAR1 (0.56) | GRM2SIGMAR1 | |
| SCHEMBL8798571 | 0.91 | SIGMAR1 (0.56) | GRM2SIGMAR1 | |
| SCHEMBL8799189 | 0.89 | GRM2 (0.56) | GRM2SIGMAR1HTR7 | |
| SCHEMBL8799705 | 0.88 | GRM2 (0.56) | GRM2SIGMAR1HTR7 | |
| SCHEMBL8799739 | 0.87 | GRM2 (0.54) | GRM2SIGMAR1HTR7 | |
| SCHEMBL8798501 | 0.87 | SIGMAR1 (0.56) | GRM2SIGMAR1HTR7 | |
| SCHEMBL9087827 | 0.87 | SIGMAR1 (0.56) | GRM2SIGMAR1HTR7 | |
| SCHEMBL8799071 | 0.86 | GRM2 (0.63) | GRM2SIGMAR1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635505-B1 | 4-Aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GMBH (DE) | 1997-10-15 | — | — | EP | disclosed |
| US-5561145-A | 4-aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESHRANKTER HAFTUNG (DE) | 1996-10-01 | — | — | US | disclosed |
| EP-0635505-A1 | 4-Aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GmbH (DE) | 1995-01-25 | — | — | EP | disclosed |