Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 5/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.43 |
| ▸ | PPARG | P37231 | 10/20 | 0.42 |
| ▸ | PPARA | Q07869 | 8/20 | 0.42 |
| ▸ | PPARD | Q03181 | 8/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9119163 | 0.87 | PPARG (0.43) | ITGB3ITGA2BPPARGPPARAPPARD | |
| SCHEMBL9119824 | 0.86 | MAPK1 (0.39) | PPARGPPARALTA4H | |
| SCHEMBL9121439 | 0.82 | MEN1 (0.43) | PPARGPPARAPPARD | |
| SCHEMBL8466647 | 0.80 | CYP4F2 (0.37) | PPARGPPARA | |
| SCHEMBL8802031 | 0.78 | CYP4F2 (0.40) | PPARGPPARA | |
| SCHEMBL8800010 | 0.78 | CYP4F2 (0.40) | PPARGPPARA | |
| SCHEMBL8799349 | 0.78 | CYP4F2 (0.40) | PPARGPPARA | |
| SCHEMBL8800173 | 0.78 | CYP4F2 (0.40) | PPARGPPARA | |
| SCHEMBL9118405 | 0.78 | CYP4F2 (0.40) | PPARGPPARA | |
| SCHEMBL5991826 | 0.78 | PPARA (0.63) | ITGB3ITGA2BPPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755381-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B 4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028386-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-10-26 | — | — | WO | disclosed |
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |