SCHEMBL8799349

SCHEMBL8799349

COC(=O)CCCCCOC(Cc1ccccc1CCCCCCOS(C)(=O)=O)C(=O)OC

nearest known ligand 0.40

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 1/20 0.40
CYP4A11 Q02928 1/20 0.40
PPARG P37231 2/20 0.36
LTB4R Q15722 1/20 0.36
PTPRC P08575 2/20 0.35
PTPN13 Q12923 1/20 0.35
PPARA Q07869 1/20 0.35
HPGD P15428 1/20 0.34
TDP1 Q9NUW8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8802031 1.00 CYP4F2 (0.40) CYP4F2CYP4A11PPARGLTB4RPTPRC
SCHEMBL9118405 1.00 CYP4F2 (0.40) CYP4F2CYP4A11PPARGLTB4RPTPRC
SCHEMBL8800173 1.00 CYP4F2 (0.40) CYP4F2CYP4A11PPARGLTB4RPTPRC
SCHEMBL8800010 1.00 CYP4F2 (0.40) CYP4F2CYP4A11PPARGLTB4RPTPRC
SCHEMBL8466647 0.98 CYP4F2 (0.37) CYP4F2CYP4A11PPARGLTB4RPTPRC
SCHEMBL8798968 0.90 PPARD (0.34) CYP4F2CYP4A11PPARGPPARATDP1
SCHEMBL9118208 0.89 PTGS2 (0.33) CYP4F2CYP4A11PPARGPPARA
SCHEMBL6760697 0.86 CYP4F2 (0.42) CYP4F2CYP4A11PPARGLTB4RPTPRC
SCHEMBL8799468 0.86 ALDH1A1 (0.43) PPARGPPARA
SCHEMBL9120935 0.84

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0755381-A1 SUBSTITUTED PYRIDINE LEUKOTRIENE B 4 ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 1997-01-29 EP disclosed
WO-1995028386-A1 SUBSTITUTED PYRIDINE LEUKOTRIENE B4 ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 1995-10-26 WO disclosed
US-5434186-A Antiinflammatory agents HOFFMANN-LA ROCHE INC. (US) 1995-07-18 US disclosed
US-5273999-A A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative HOFFMANN-LA ROCHE INC. (US) 1993-12-28 US disclosed
EP-0531823-A1 Bicyclic carboxylic acid derivatives as anti-inflammatory agents F. HOFFMANN-LA ROCHE AG (CH) 1993-03-17 EP disclosed