Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.61 |
| ▸ | PPARA | Q07869 | 9/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9079478 | 0.91 | PPARG (0.59) | PPARGPPARACYP2C9KCNH2KDR | |
| SCHEMBL4744450 | 0.88 | KDR (0.61) | PPARGPPARACYP2C9KCNH2KDR | |
| SCHEMBL8799156 | 0.87 | KDR (0.76) | PPARGPPARACYP2C9KCNH2KDR | |
| SCHEMBL8545784 | 0.87 | PPARG (0.55) | PPARGPPARACYP2C9KCNH2KDR | |
| SCHEMBL4674437 | 0.86 | PPARG (0.69) | PPARGPPARACYP2C9KCNH2KDR | |
| SCHEMBL8800156 | 0.86 | PPARG (0.64) | PPARGPPARACYP2C9KCNH2KDR | |
| SCHEMBL9179217 | 0.85 | PPARG (0.60) | PPARGPPARACYP2C9KCNH2KDR | |
| SCHEMBL9176979 | 0.82 | PPARG (0.66) | PPARGPPARACYP2C9KCNH2KDR | |
| SCHEMBL5227314 | 0.82 | PPARG (0.57) | PPARGPPARACYP2C9KCNH2KDR | |
| SCHEMBL8550939 | 0.82 | MAOB (0.61) | PPARGPPARACYP2C9KCNH2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0759919-A1 | NEW AZOLIDINEDIONES AS ANTIHYPERGLYCEMIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-03-05 | — | — | EP | disclosed |