SCHEMBL8545784

SCHEMBL8545784

Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1COc1cccc(C=O)c1

nearest known ligand 0.63

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PPARG P37231 3/20 0.55
PPARA Q07869 3/20 0.55
CYP2C9 P11712 1/20 0.55
KCNH2 Q12809 1/20 0.55
PTPN1 P18031 5/20 0.53
KDR P35968 1/20 0.52
MAPT P10636 2/20 0.48
TP53 P04637 3/20 0.47
POLB P06746 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4746588 0.90 PPARG (0.61) PPARGPPARACYP2C9KCNH2
SCHEMBL8550231 0.88 PPARG (0.56) PPARGPPARACYP2C9KCNH2PTPN1
SCHEMBL8550222 0.88 PPARG (0.56) PPARGPPARACYP2C9KCNH2PTPN1
SCHEMBL9260216 0.87 PPARG (0.53) PPARGPPARACYP2C9KCNH2PTPN1
SCHEMBL8551814 0.87 KDR (0.54) PPARGPPARACYP2C9KCNH2PTPN1
SCHEMBL8551816 0.87 KDR (0.54) PPARGPPARACYP2C9KCNH2PTPN1
SCHEMBL9177105 0.87 PPARG (0.53) PPARGPPARACYP2C9KCNH2PTPN1
SCHEMBL6157414 0.87 KDR (0.67) PPARGPPARACYP2C9KCNH2KDR
SCHEMBL8799608 0.87 PPARG (0.61) PPARGPPARACYP2C9KCNH2PTPN1
SCHEMBL9181501 0.86 PPARG (0.57) PPARGPPARACYP2C9KCNH2KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0759919-B1 AZOLIDINEDIONES AS ANTIHYPERGLYCEMIC AGENTS AMERICAN HOME PROD (US) 1998-11-11 EP disclosed
CN-1152312-A Novel pyrrolidinediones as antihyperglycemic agents AMERICAN HOME PROD (US) 1997-06-18 CN disclosed
EP-0759919-A1 NEW AZOLIDINEDIONES AS ANTIHYPERGLYCEMIC AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1997-03-05 EP disclosed
US-5532256-A ORALLY ADMINISTERED ANTIDIABETIC AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1996-07-02 US disclosed
WO-1995031454-A1 NEW AZOLIDINEDIONES AS ANTIHYPERGLYCEMIC AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1995-11-23 WO disclosed
US-5468762-A Antidiabetic agents for administering by mouth AMERICAN HOME PRODUCTS CORPORATION (US) 1995-11-21 US disclosed
US-5468760-A Treating atherosclerosis, inflammation, and asthma AMERICAN HOME PRODUCTS CORPORATION (US) 1995-11-21 US disclosed