Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 10/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799972 | 1.00 | ALOX5 (0.60) | ALOX5NPC1RAB9ASMN1; SMN2EPHX2 | |
| SCHEMBL8804130 | 1.00 | ALOX5 (0.60) | ALOX5NPC1RAB9ASMN1; SMN2EPHX2 | |
| SCHEMBL8802299 | 1.00 | ALOX5 (0.60) | ALOX5NPC1RAB9ASMN1; SMN2EPHX2 | |
| SCHEMBL8800494 | 0.99 | ALOX5 (0.61) | ALOX5NPC1RAB9ASMN1; SMN2EPHX2 | |
| SCHEMBL8800571 | 0.99 | ALOX5 (0.61) | ALOX5NPC1RAB9ASMN1; SMN2EPHX2 | |
| SCHEMBL8800408 | 0.99 | ALOX5 (0.61) | ALOX5NPC1RAB9ASMN1; SMN2EPHX2 | |
| SCHEMBL9564300 | 0.82 | ALOX5 (0.67) | ALOX5NPC1RAB9ASMN1; SMN2EPHX2 | |
| SCHEMBL8799791 | 0.81 | ALOX5 (0.68) | ALOX5HDAC6 | |
| SCHEMBL8800756 | 0.81 | ALOX5 (0.68) | ALOX5HDAC6 | |
| SCHEMBL8799716 | 0.81 | ALOX5 (0.68) | ALOX5HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772594-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | Abbott Laboratories (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996002507-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1996-02-01 | — | — | WO | disclosed |