Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 9/20 | 0.43 |
| ▸ | LDHA | P00338 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799802 | 0.86 | MEN1 (0.46) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8799579 | 0.85 | PTGER1 (0.48) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8799486 | 0.84 | PTGER1 (0.44) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8798822 | 0.83 | ALDH1A1 (0.46) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8799153 | 0.83 | PTGER1 (0.58) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8799447 | 0.83 | HTR2A (0.44) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8799822 | 0.82 | MEN1 (0.44) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8798835 | 0.82 | PTGER1 (0.51) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8799893 | 0.82 | ALDH1A1 (0.44) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8798838 | 0.80 | HTT (0.45) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696283-B1 | 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- AND/OR 10-SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | SEARLE & CO (US) | 1997-09-17 | — | — | EP | disclosed |
| US-5395932-A | Analgesics, prostaglandin E2 inhibitors | G. D. SEARLE & CO. (US) | 1995-03-07 | — | — | US | disclosed |
| WO-1994025456-A1 | 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- AND/OR 10-SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1994-11-10 | — | — | WO | disclosed |