Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | AMPD1 | P23109 | 2/20 | 0.35 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 5/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928075 | 1.00 | CYP11B1 (0.41) | CYP11B1CYP11B2TBXAS1TLR8ALDH1A1 | |
| SCHEMBL6926786 | 1.00 | CYP11B1 (0.41) | CYP11B1CYP11B2TBXAS1TLR8ALDH1A1 | |
| SCHEMBL6926318 | 0.98 | CYP11B1 (0.42) | CYP11B1CYP11B2TBXAS1TLR8ALDH1A1 | |
| SCHEMBL9597354 | 0.87 | CYP11B1 (0.43) | CYP11B1CYP11B2TBXAS1TLR8ALDH1A1 | |
| SCHEMBL5391398 | 0.85 | CYP11B1 (0.45) | CYP11B1CYP11B2 | |
| SCHEMBL1075247 | 0.82 | TBXAS1 (0.47) | CYP11B1CYP11B2TBXAS1TLR8ALDH1A1 | |
| SCHEMBL7247430 | 0.82 | CYP11B1 (0.46) | CYP11B1CYP11B2TBXAS1AMPD2 | |
| Hydrochloric Acid SCHEMBL6926010 | 0.81 | TLR8 (0.39) | TBXAS1TLR8ALDH1A1TDP1MGLL | |
| Hydrochloric Acid SCHEMBL6926145 | 0.81 | TLR8 (0.39) | TBXAS1TLR8ALDH1A1TDP1MGLL | |
| SCHEMBL9570273 | 0.80 | TBXAS1 (0.40) | CYP11B1CYP11B2TBXAS1TLR8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0482771-B1 | Heterocyclic acids | ZENECA LTD (GB) | 1997-06-18 | — | — | EP | disclosed |
| US-5410064-A | Thromboxane A2 antagonists and inhibitors of thromboxane A2 synthase | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-04-25 | — | — | US | disclosed |
| US-5219874-A | Heterocyclic acids | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-15 | — | — | US | disclosed |
| EP-0482771-A2 | Heterocyclic acids | ZENECA LIMITED (GB) | 1992-04-29 | — | — | EP | disclosed |