Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.49 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.49 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801840 | 0.93 | GPBAR1 (0.53) | CYSLTR1CYSLTR2GPBAR1ALOX5MAPK1 | |
| SCHEMBL8800305 | 0.79 | CYSLTR1 (0.52) | CYSLTR1CYSLTR2GPBAR1ALOX5FFAR1 | |
| SCHEMBL8137925 | 0.78 | MAOB (0.56) | CYSLTR1CYSLTR2GPBAR1ALOX5FFAR1 | |
| Ammonia Solution, Strong SCHEMBL9585183 | 0.74 | CYSLTR1 (0.69) | CYSLTR1CYSLTR2GPBAR1ALOX5MAPK1 | |
| SCHEMBL8802132 | 0.74 | GPBAR1 (0.55) | CYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL8800332 | 0.73 | CYSLTR1 (0.51) | CYSLTR1CYSLTR2GPBAR1ALOX5FFAR1 | |
| SCHEMBL29587847 | 0.72 | CYSLTR1 (0.68) | CYSLTR1CYSLTR2GPBAR1ALOX5FFAR1 | |
| SCHEMBL10632839 | 0.72 | GPBAR1 (0.76) | CYSLTR1CYSLTR2GPBAR1ALOX5MAPK1 | |
| SCHEMBL15271902 | 0.71 | GPBAR1 (0.77) | CYSLTR1CYSLTR2GPBAR1ALOX5MAPK1 | |
| SCHEMBL8029083 | 0.70 | CYSLTR1 (0.61) | CYSLTR1CYSLTR2GPBAR1ALOX5MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799826-A1 | Heteroaryl substituted phenylene derivatives, their preparation and their use as leukotriene receptor antagonists | KOWA CO. LTD. (JP) | 1997-10-08 | — | — | EP | disclosed |