Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 7/20 | 0.40 |
| ▸ | CTSL | P07711 | 5/20 | 0.36 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.36 |
| ▸ | RBPJ | Q06330 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | OXTR | P30559 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801769 | 0.93 | BRD4 (0.37) | CTSBCTSLFNTAFNTBBRD4 | |
| SCHEMBL8801630 | 0.93 | FNTA (0.43) | CTSBCTSLFNTAFNTBBRD4 | |
| Tetrazole SCHEMBL8801092 | 0.87 | CTSB (0.40) | CTSBCTSLNOTCH1RBPJFNTA | |
| SCHEMBL8801991 | 0.83 | FNTA (0.47) | CTSBFNTAFNTBTP53SMN1; SMN2 | |
| Tetrazole SCHEMBL8801776 | 0.81 | CTSB (0.38) | CTSBCTSLMAPTNPSR1MCL1 | |
| Tetrazole SCHEMBL8801643 | 0.81 | FNTA (0.41) | CTSBCTSLFNTAFNTBMAPT | |
| SCHEMBL8800443 | 0.79 | CTSB (0.38) | CTSBCTSLFNTAFNTBMAPT | |
| SCHEMBL8800911 | 0.79 | FNTA (0.45) | CTSBCTSLFNTAFNTBMAPT | |
| SCHEMBL8669346 | 0.78 | HTR2B (0.41) | NOTCH1RBPJBRD4BRD2BRD3 | |
| SCHEMBL8940465 | 0.77 | FNTA (0.60) | FNTAFNTBTP53SMN1; SMN2OXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994026723-A2 | ras FARNESYL TRANSFERASE INHIBITORS | GENENTECH, INC. (US) | 1994-11-24 | — | — | WO | claimed |
| EP-0763537-A2 | Non-peptidyl Ras farnesyl transferase inhibitors | GENENTECH, INC. (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0698015-A1 | PREPARATION OF N-CYANODITHIOIMINO-CARBONATES AND 3-MERCAPTO-5-AMINO-1H-1,2,4-TRIAZOLE | GENENTECH, INC. (US) | 1996-02-28 | — | — | EP | disclosed |
| WO-1994026723-A2 | ras FARNESYL TRANSFERASE INHIBITORS | GENENTECH, INC. (US) | 1994-11-24 | — | — | WO | disclosed |