Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | CCKBR | P32239 | 11/20 | 0.43 |
| ▸ | CCKAR | P32238 | 9/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | OXTR | P30559 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801265 | 1.00 | KCNH2 (0.56) | KCNH2ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL7090389 | 0.89 | KCNH2 (0.60) | KCNH2ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL7090394 | 0.89 | KCNH2 (0.60) | KCNH2ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL8608963 | 0.89 | KCNH2 (0.60) | KCNH2ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL8608811 | 0.88 | KCNH2 (0.59) | KCNH2ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL8713101 | 0.88 | KCNH2 (0.59) | KCNH2ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL7213180 | 0.84 | KCNH2 (0.63) | KCNH2ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL7092438 | 0.72 | KCNH2 (0.48) | KCNH2ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL7090700 | 0.72 | KCNH2 (1.00) | KCNH2HDAC1CCKBRCCKARPSEN1 | |
| SCHEMBL7087129 | 0.72 | KCNH2 (1.00) | KCNH2HDAC1CCKBRCCKARPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5679672-A | ANITARRHYTHMIC AGENTS | MERCK & CO., INC. (US) | 1997-10-21 | — | — | US | disclosed |
| EP-0730596-A4 | BENZODIAZEPINES | MERCK & CO INC (US) | 1997-07-30 | — | — | EP | disclosed |
| EP-0730596-A1 | BENZODIAZEPINES | MERCK & CO. INC. (US) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995014694-A1 | BENZODIAZEPINES | MERCK & CO., INC. (US) | 1995-06-01 | — | — | WO | disclosed |