Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 10/20 | 0.59 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30099082 | 1.00 | MKNK2 (0.59) | MKNK2MKNK1CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL28303127 | 0.83 | MKNK2 (0.60) | MKNK2MKNK1CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL28303123 | 0.81 | MKNK2 (0.58) | MKNK2MKNK1GSK3BIRAK4 | |
| SCHEMBL23413110 | 0.81 | MKNK2 (0.58) | MKNK2MKNK1EGFRPI4KAPI4K2B | |
| SCHEMBL29484990 | 0.79 | MKNK2 (0.56) | MKNK2MKNK1CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL28317574 | 0.78 | MKNK2 (0.55) | MKNK2MKNK1JAK2JAK3IRAK4 | |
| SCHEMBL28316686 | 0.77 | MKNK2 (0.53) | MKNK2MKNK1JAK2JAK3 | |
| SCHEMBL18789209 | 0.74 | MKNK2 (1.00) | MKNK2MKNK1MAPK9 | |
| SCHEMBL30093014 | 0.74 | MKNK2 (0.62) | MKNK2MKNK1CDC7CDK2 | |
| SCHEMBL23412407 | 0.74 | MKNK2 (0.62) | MKNK2MKNK1CDC7CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0482804-B1 | Pyrrolo[2,3-d]pyrimidines with cardiovascular activity, process for their preparation and pharmaceutical compositions containing them | ZENECA LTD (GB) | 1997-01-22 | — | — | EP | disclosed |
| US-5328910-A | Bradycardial agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-07-12 | — | — | US | disclosed |
| EP-0482804-A1 | Pyrrolo[2,3-d]pyrimidines with cardiovascular activity, process for their preparation and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 1992-04-29 | — | — | EP | disclosed |