Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 10/20 | 0.59 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801410 | 1.00 | MKNK2 (0.59) | MKNK2MKNK1CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL28303127 | 0.83 | MKNK2 (0.60) | MKNK2MKNK1CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL28303123 | 0.81 | MKNK2 (0.58) | MKNK2MKNK1GSK3BIRAK4 | |
| SCHEMBL23413110 | 0.81 | MKNK2 (0.58) | MKNK2MKNK1EGFRPI4KAPI4K2B | |
| SCHEMBL29484990 | 0.79 | MKNK2 (0.56) | MKNK2MKNK1CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL28317574 | 0.78 | MKNK2 (0.55) | MKNK2MKNK1JAK2JAK3IRAK4 | |
| SCHEMBL28316686 | 0.77 | MKNK2 (0.53) | MKNK2MKNK1JAK2JAK3 | |
| SCHEMBL18789209 | 0.74 | MKNK2 (1.00) | MKNK2MKNK1MAPK9 | |
| SCHEMBL30093014 | 0.74 | MKNK2 (0.62) | MKNK2MKNK1CDC7CDK2 | |
| SCHEMBL23412407 | 0.74 | MKNK2 (0.62) | MKNK2MKNK1CDC7CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12612424-B2 | HPK1 inhibitors and uses thereof | REGOR PHARMACEUTICALS, INC. (US) | 2026-04-28 | — | — | US | disclosed |
| US-20220389037-A1 | HPK1 INHIBITORS AND USES THEREOF | REGOR PHARMACEUTICALS, INC. | 2022-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12612424-B2 | HPK1 inhibitors and uses thereof | NEK11, NEK1, CSNK1A1 | MKNK2 190/4885MKNK1 121/4885CYP1A2 3048/4885 |
| US-20220389037-A1 | HPK1 INHIBITORS AND USES THEREOF | HIPK1, SIK1, PGK1 | MKNK2 87/4885MKNK1 32/4885CYP1A2 3915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.