Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 8/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.50 |
| ▸ | HTR3B | O95264 | 4/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22045105 | 0.85 | MAOB (0.44) | ALDH1A1MAP4K4PARP1MAPT | |
| SCHEMBL10322127 | 0.81 | MAP4K4 (0.57) | HTR3AHRH4HTR3EHTR3BHTR3D | |
| SCHEMBL8802519 | 0.76 | KDM4E (0.44) | HTR3AHRH4HTR3EHTR3BHTR3D | |
| SCHEMBL8802527 | 0.76 | KDM4E (0.44) | HTR3AHRH4HTR3EHTR3BHTR3D | |
| SCHEMBL3570254 | 0.76 | HTR3A (0.56) | HTR3AHRH4HTR3EHTR3BHTR3D | |
| SCHEMBL23769666 | 0.75 | PDE10A (0.38) | — | |
| SCHEMBL23769660 | 0.75 | PIM1 (0.33) | ALDH1A1CYP1A2KMT2A | |
| SCHEMBL27108980 | 0.75 | HTR3A (0.63) | HTR3AHRH4HTR3EHTR3BHTR3D | |
| SCHEMBL23769652 | 0.73 | PDE10A (0.30) | — | |
| SCHEMBL31533226 | 0.72 | HRH3 (0.44) | HTR3AHRH4HTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0627432-B1 | 6-Piperazinyl-1H-pyrazolo [3,4-b]pyridine-3-carboxylic Acids, Esters, Amides and related compounds, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0627432-A1 | 6-Piperazinyl-1H-pyrazolo [3,4-b]pyridine-3-carboxylic Acids, Esters, Amides andrelated compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-12-07 | — | — | EP | disclosed |
| US-5300498-A | Treating depression, obsessive compulsive disorder | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-04-05 | — | — | US | disclosed |