Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6519468 | 1.00 | MAPT (0.43) | MAPTL3MBTL1SMN1; SMN2NPC1CYP2C9 | |
| SCHEMBL6518890 | 1.00 | MAPT (0.43) | MAPTL3MBTL1SMN1; SMN2NPC1CYP2C9 | |
| SCHEMBL6518886 | 1.00 | MAPT (0.43) | MAPTL3MBTL1SMN1; SMN2NPC1CYP2C9 | |
| SCHEMBL880174 | 0.87 | EIF2S1 (0.37) | KMT2A | |
| SCHEMBL880173 | 0.87 | EIF2S1 (0.37) | KMT2A | |
| SCHEMBL6520061 | 0.86 | EIF2S1 (0.39) | SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL880181 | 0.83 | MAPT (0.44) | MAPTL3MBTL1SMN1; SMN2NPC1CYP2C9 | |
| SCHEMBL880168 | 0.81 | EIF2AK3 (0.37) | — | |
| SCHEMBL880175 | 0.81 | EIF2AK3 (0.37) | — | |
| SCHEMBL6518734 | 0.81 | EIF2AK3 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546613-B2 | SGK1 inhibitors for the prophylaxis and/or therapy of viral diseases and/or carcinomas | MERCK PATENT GMBH (DE) | 2013-10-01 | — | — | US | disclosed |
| EP-2242738-B1 | SGK1 INHIBITORS FOR THE PROPHYLAXIS AND/OR THERAPY OF VIRAL DISEASES AND/OR CARCINOMAS | MERCK PATENT GMBH (DE) | 2012-03-28 | — | — | EP | disclosed |
| US-20110060050-A1 | SGK1 INHIBITORS FOR THE PROPHYLAXIS AND/OR THERAPY OF VIRAL DISEASES AND/OR CARCINOMAS | MERCK PATENT GMBH (DE) | 2011-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110060050-A1 | SGK1 INHIBITORS FOR THE PROPHYLAXIS AND/OR THERAPY OF VIRAL DISEASES AND/OR CARCINOMAS | NCOA1, NR3C2, NCOA2 | MAPT 2569/4885L3MBTL1 2152/4885SMN1; SMN2 2634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.