Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC33A1 | O00400 | 2/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9270320 | 0.91 | AGTR1 (0.32) | AGTR1LTB4R2AGTR2 | |
| SCHEMBL8800864 | 0.87 | — | — | |
| SCHEMBL8801692 | 0.86 | SLC33A1 (0.38) | SLC33A1AGTR1LTB4R2 | |
| SCHEMBL8672202 | 0.86 | SLC33A1 (0.38) | SLC33A1 | |
| SCHEMBL8801137 | 0.84 | SLC33A1 (0.38) | SLC33A1 | |
| SCHEMBL8801639 | 0.84 | SLC33A1 (0.39) | SLC33A1 | |
| SCHEMBL8801841 | 0.82 | SLC33A1 (0.37) | SLC33A1AGTR1LTB4R2 | |
| SCHEMBL8801815 | 0.82 | SLC33A1 (0.37) | SLC33A1AGTR1AGTR2 | |
| SCHEMBL8801884 | 0.82 | SLC33A1 (0.40) | SLC33A1 | |
| SCHEMBL8801784 | 0.81 | AGTR1 (0.46) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680480-B1 | PYRIMIDINONE DERIVATIVES FUSED TO NITROGEN HETEROCYCLES HAVING A II ANTAGONISTIC ACTIVITY | LUSO FARMACO INST (IT) | 1997-07-30 | — | — | EP | claimed |
| WO-1994017067-A1 | PYRIMIDINONE DERIVATIVES FUSED TO NITROGEN HETEROCYCLES HAVING A II ANTAGONISTIC ACTIVITY | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1994-08-04 | — | — | WO | claimed |
| EP-0800504-A1 | TRICYCLIC RETINOIDS, METHODS FOR THEIR PRODUCTION AND USE | LIGAND PHARMACEUTICALS, INC. (US) | 1997-10-15 | — | — | EP | disclosed |
| EP-0680480-B1 | PYRIMIDINONE DERIVATIVES FUSED TO NITROGEN HETEROCYCLES HAVING A II ANTAGONISTIC ACTIVITY | LUSO FARMACO INST (IT) | 1997-07-30 | — | — | EP | disclosed |
| WO-1994017067-A1 | PYRIMIDINONE DERIVATIVES FUSED TO NITROGEN HETEROCYCLES HAVING A II ANTAGONISTIC ACTIVITY | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1994-08-04 | — | — | WO | disclosed |