Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.55 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.52 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.52 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801668 | 0.87 | CYSLTR1 (0.62) | PDE10AALOX5GPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL8799782 | 0.84 | PDE10A (0.59) | PDE10AALOX5GPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL8802120 | 0.84 | PDE10A (0.55) | PDE10AALOX5GPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL9756934 | 0.82 | CYSLTR1 (0.60) | PDE10AALOX5GPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL9757134 | 0.82 | CYSLTR1 (0.58) | PDE10AALOX5GPBAR1CYSLTR1 | |
| SCHEMBL9756941 | 0.82 | CYSLTR1 (0.54) | PDE10AALOX5GPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL9757258 | 0.81 | CYSLTR1 (0.60) | PDE10AALOX5GPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL9757208 | 0.81 | CYSLTR1 (0.61) | PDE10AALOX5GPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL8800491 | 0.77 | PDE10A (0.60) | PDE10AALOX5GPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL10512475 | 0.75 | PDE10A (0.77) | PDE10AGPBAR1CYSLTR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772594-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | Abbott Laboratories (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996002507-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1996-02-01 | — | — | WO | disclosed |