Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.62 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.62 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.61 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.55 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9756934 | 0.95 | CYSLTR1 (0.60) | CYSLTR1GPBAR1PDE10ACYSLTR2FFAR1 | |
| SCHEMBL9757258 | 0.93 | CYSLTR1 (0.60) | CYSLTR1GPBAR1PDE10ACYSLTR2ALOX5 | |
| SCHEMBL8802122 | 0.87 | PDE10A (0.57) | CYSLTR1GPBAR1PDE10ACYSLTR2ALOX5 | |
| SCHEMBL8799782 | 0.86 | PDE10A (0.59) | CYSLTR1GPBAR1PDE10ACYSLTR2ALOX5AP | |
| SCHEMBL9757134 | 0.86 | CYSLTR1 (0.58) | CYSLTR1GPBAR1PDE10AALOX5APFFAR1 | |
| SCHEMBL8802120 | 0.85 | PDE10A (0.55) | CYSLTR1GPBAR1PDE10ACYSLTR2ALOX5AP | |
| SCHEMBL9756941 | 0.85 | CYSLTR1 (0.54) | CYSLTR1GPBAR1PDE10ACYSLTR2FFAR1 | |
| SCHEMBL9757208 | 0.84 | CYSLTR1 (0.61) | CYSLTR1GPBAR1PDE10ACYSLTR2ALOX5AP | |
| SCHEMBL5564372 | 0.82 | TBXAS1 (0.54) | — | |
| SCHEMBL9757101 | 0.82 | CYSLTR1 (0.46) | CYSLTR1GPBAR1PDE10ACYSLTR2ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772594-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | Abbott Laboratories (US) | 1997-05-14 | — | — | EP | disclosed |
| US-5512581-A | ANTIINFLAMMATORY AGENT | ABBOTT LABORATORIES (US) | 1996-04-30 | — | — | US | disclosed |
| WO-1996002507-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1996-02-01 | — | — | WO | disclosed |