Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 5/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14942712 | 0.88 | SMN1; SMN2 (0.64) | LMNAALDH1A1MAPK1TDP1SMN1; SMN2 | |
| SCHEMBL880388 | 0.86 | LMNA (0.66) | LMNAALDH1A1MAPK1TDP1SMN1; SMN2 | |
| SCHEMBL852442 | 0.86 | LMNA (0.72) | LMNAALDH1A1MAPK1TDP1SMN1; SMN2 | |
| SCHEMBL880485 | 0.85 | LMNA (0.58) | LMNAALDH1A1MAPK1TDP1SMN1; SMN2 | |
| SCHEMBL14095231 | 0.84 | LMNA (0.57) | LMNAALDH1A1MAPK1TDP1SMN1; SMN2 | |
| SCHEMBL880270 | 0.84 | TP53 (0.73) | LMNAALDH1A1MAPK1TDP1SMN1; SMN2 | |
| SCHEMBL880430 | 0.84 | LMNA (0.67) | LMNAALDH1A1MAPK1TDP1SMN1; SMN2 | |
| SCHEMBL880450 | 0.84 | LMNA (0.66) | LMNAALDH1A1MAPK1TDP1SMN1; SMN2 | |
| SCHEMBL10280365 | 0.84 | LMNA (0.66) | LMNAALDH1A1MAPK1TDP1SMN1; SMN2 | |
| SCHEMBL10280289 | 0.83 | LMNA (0.62) | LMNAALDH1A1MAPK1TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440705-B2 | 2,3,4,7,8,9-hexahydro-1H-cyclopenta[h]quinolin-2-one or 2,3,4,6,7,8-hexahydro-1H-cyclopenta[g]quinolin-2-one; Alzheimer's disease | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2013-05-14 | — | — | US | disclosed |
| EP-2433634-A2 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-03-28 | — | — | EP | disclosed |