Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | IDO1 | P14902 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL880307 | 0.89 | IDO1 (0.70) | HSD17B10LMNAMAPTIDO1SMN1; SMN2 | |
| SCHEMBL880232 | 0.84 | HSD17B10 (0.62) | HSD17B10LMNAMAPTIDO1SMN1; SMN2 | |
| SCHEMBL15359680 | 0.84 | HSD17B10 (0.62) | HSD17B10LMNAMAPTIDO1SMN1; SMN2 | |
| SCHEMBL880297 | 0.84 | LMNA (0.64) | HSD17B10LMNAMAPTIDO1SMN1; SMN2 | |
| SCHEMBL14047395 | 0.84 | HSD17B10 (0.62) | HSD17B10LMNAMAPTIDO1SMN1; SMN2 | |
| SCHEMBL880273 | 0.83 | HSD17B10 (0.58) | HSD17B10LMNAMAPTIDO1SMN1; SMN2 | |
| SCHEMBL852442 | 0.82 | LMNA (0.72) | HSD17B10LMNAMAPTIDO1SMN1; SMN2 | |
| SCHEMBL880437 | 0.82 | LMNA (0.61) | HSD17B10LMNAMAPTIDO1SMN1; SMN2 | |
| SCHEMBL14450608 | 0.82 | LMNA (0.61) | HSD17B10LMNAMAPTIDO1SMN1; SMN2 | |
| SCHEMBL880355 | 0.82 | HSD17B10 (0.59) | HSD17B10LMNAMAPTIDO1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433634-A2 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-03-28 | — | — | EP | disclosed |