Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 9/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.68 |
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | TSHR | P16473 | 5/20 | 0.68 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.68 |
| ▸ | PGR | P06401 | 5/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.68 |
| ▸ | SHBG | P04278 | 4/20 | 0.68 |
| ▸ | SERPINA6 | P08185 | 4/20 | 0.68 |
| ▸ | AR | P10275 | 4/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.68 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.68 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8803302 | 1.00 | LMNA (0.68) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8803310 | 1.00 | LMNA (0.68) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8802536 | 0.89 | LMNA (0.72) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8802540 | 0.89 | LMNA (0.72) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8802547 | 0.89 | LMNA (0.72) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7531953 | 0.88 | CYP3A4 (0.73) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL11157648 | 0.88 | CYP3A4 (0.73) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7531942 | 0.88 | CYP3A4 (0.73) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8804072 | 0.86 | LMNA (0.73) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8804080 | 0.86 | LMNA (0.73) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540717-B1 | UNSATURATED 17$g(b)-SUBSTITUTED 3-CARBOXY STEROIDS | PHARMACIA & UPJOHN SPA (IT) | 1997-07-23 | — | — | EP | disclosed |
| US-5212166-A | Antiandrogens or 5-alpha reductase inhibitors | FARMITALIA CARLO ERBA S.R.L. (IT) | 1993-05-18 | — | — | US | disclosed |
| EP-0540717-A1 | UNSATURATED 17-g(b)-SUBSTITUTED 3-CARBOXY STEROIDS. | ERBA CARLO SPA (IT) | 1993-05-12 | — | — | EP | disclosed |
| EP-0517047-A1 | Unsaturated 17beta-substituted 3-carboxy steroids | FARMITALIA CARLO ERBA S.r.l. (IT) | 1992-12-09 | — | — | EP | disclosed |
| WO-1992020700-A1 | UNSATURATED 17β-SUBSTITUTED 3-CARBOXY STEROIDS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-11-26 | — | — | WO | disclosed |