Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8803421 | 0.82 | KMT2A (0.53) | MAOAMAOBP2RY1 | |
| SCHEMBL8803427 | 0.82 | KMT2A (0.53) | MAOAMAOBP2RY1 | |
| SCHEMBL8804441 | 0.80 | CYP2D6 (0.42) | MAOAMAOBCYP2D6CYP2C19ACHE | |
| SCHEMBL8803896 | 0.78 | P2RY1 (0.52) | MAOAMAOBPTGS1PTGS2ALOX5 | |
| SCHEMBL8803557 | 0.76 | KDM4E (0.48) | MAOAMAOBPTGS1PTGS2ALOX5 | |
| SCHEMBL8803559 | 0.76 | KDM4E (0.48) | MAOAMAOBPTGS1PTGS2ALOX5 | |
| SCHEMBL8803889 | 0.74 | EPHX2 (0.54) | — | |
| SCHEMBL8803890 | 0.74 | EPHX2 (0.54) | — | |
| Hydrochloric Acid SCHEMBL8946231 | 0.74 | F10 (0.42) | — | |
| SCHEMBL8805752 | 0.72 | CYP2D6 (0.48) | MAOAMAOBCYP2D6CYP2C19ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625507-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-07-23 | — | — | EP | disclosed |
| US-5621010-A | ANTIHYPERCHOLESTEROLEMIA AND ANTIATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-04-15 | — | — | US | disclosed |
| EP-0625507-A2 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1994-11-23 | — | — | EP | disclosed |