Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8804441 | 0.93 | CYP2D6 (0.42) | CYP2D6CYP2C19PKMMAOBMAOA | |
| SCHEMBL8802406 | 0.87 | MAOB (0.52) | MAOBMAOAKMT2A | |
| SCHEMBL8806034 | 0.86 | KMT2A (0.59) | PKMMAOBMAOAKMT2A | |
| SCHEMBL8804783 | 0.85 | KMT2A (0.61) | PKMMAOBMAOAKMT2ATSHR | |
| SCHEMBL8803907 | 0.85 | KMT2A (0.61) | PKMMAOBMAOAKMT2ATSHR | |
| SCHEMBL8805456 | 0.85 | KMT2A (0.61) | PKMMAOBMAOAKMT2ATSHR | |
| SCHEMBL8803651 | 0.85 | KMT2A (0.61) | PKMMAOBMAOAKMT2ATSHR | |
| SCHEMBL8807223 | 0.84 | KMT2A (0.48) | CYP2D6CYP2C19MAOBMAOAKMT2A | |
| SCHEMBL8805035 | 0.84 | KMT2A (0.48) | CYP2D6CYP2C19MAOBMAOAKMT2A | |
| SCHEMBL8804108 | 0.84 | ALDH1A1 (0.51) | MAOBMAOAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625507-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-07-23 | — | — | EP | disclosed |
| US-5621010-A | ANTIHYPERCHOLESTEROLEMIA AND ANTIATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-04-15 | — | — | US | disclosed |
| EP-0625507-A2 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1994-11-23 | — | — | EP | disclosed |