Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL880487 | 0.86 | LMNA (0.67) | LMNAKMT2ANPC1MEN1RAB9A | |
| SCHEMBL14047425 | 0.86 | TDP1 (0.52) | LMNAKMT2ANPC1MEN1RAB9A | |
| SCHEMBL10280723 | 0.86 | KDM4E (0.56) | LMNAKMT2ANPC1MEN1RAB9A | |
| SCHEMBL880230 | 0.86 | KMT2A (0.67) | LMNAKMT2ANPC1MEN1RAB9A | |
| SCHEMBL880374 | 0.83 | LMNA (0.64) | LMNAKMT2ANPC1MEN1RAB9A | |
| SCHEMBL10280623 | 0.83 | KMT2A (0.47) | LMNAKMT2ANPC1MEN1RAB9A | |
| SCHEMBL880247 | 0.83 | MEN1 (0.47) | LMNAKMT2ANPC1MEN1RAB9A | |
| SCHEMBL880489 | 0.79 | LMNA (0.49) | LMNAKMT2ANPC1MEN1RAB9A | |
| SCHEMBL15359830 | 0.79 | LMNA (0.41) | LMNAKMT2ANPC1MEN1RAB9A | |
| SCHEMBL10280622 | 0.77 | LMNA (0.59) | LMNAKMT2ANPC1MEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433634-A2 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-03-28 | — | — | EP | disclosed |