Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 5/20 | 0.35 |
| ▸ | HTR1A | P08908 | 4/20 | 0.35 |
| ▸ | HTR1B | P28222 | 4/20 | 0.35 |
| ▸ | PTPRZ1 | P23471 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852624 | 0.78 | CA1 (0.40) | CXCR2HSD11B1CA1CA2CXCR1 | |
| SCHEMBL7952665 | 0.76 | CA1 (0.39) | CXCR2HSD11B1CA1CA2CXCR1 | |
| SCHEMBL10415286 | 0.76 | ABL1 (0.42) | ABL1CHRM5 | |
| SCHEMBL1748982 | 0.75 | P4HTM (0.50) | CXCR2CXCR1 | |
| SCHEMBL752015 | 0.75 | CXCR2 (0.39) | CXCR2HSD11B1CA1CA2CXCR1 | |
| SCHEMBL1063185 | 0.75 | CACNA1I (0.40) | — | |
| SCHEMBL16422623 | 0.74 | PPARA (0.47) | CXCR2HSD11B1CA1CA2CXCR1 | |
| SCHEMBL17967042 | 0.74 | CYSLTR2 (0.41) | — | |
| SCHEMBL5254572 | 0.74 | HRH3 (0.55) | CA1CA2ABL1DRD2DRD3 | |
| SCHEMBL10678544 | 0.73 | KMT2A (0.47) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1039324-C | Substituted azacyclo-pyrimidine compounds, their pharmaceutical salts or N-oxides, and their use as anti-inflammatory agents | AMERICAN HOME PROD (US) | 1998-07-29 | — | — | CN | disclosed |
| CN-1175414-A | Method for preparing substd. azacyclopyrimidine compound, its pharmaceutic salt or N-oxide | AMERICAN HOME PROD (US) | 1998-03-11 | — | — | CN | disclosed |
| EP-0539086-B1 | Condensed pyrimidine derivatives and their use as angiotensine II antagonists | AMERICAN HOME PROD (US) | 1997-12-29 | — | — | EP | disclosed |
| US-5498776-A | Substituted pyrrolopyrimidines and pyridopyrimidines useful as angiotensin II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-03-12 | — | — | US | disclosed |
| US-5256654-A | Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-26 | — | — | US | disclosed |
| CN-1072682-A | SUBSTITUTED PYRIMIDINES | AMERICAN HOME PROD (US) | 1993-06-02 | — | — | CN | disclosed |
| EP-0539086-A2 | Condensed pyrimidine derivatives and their use as angiotensine II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| US-5149699-A | Substituted pyridopyrimidines useful as antgiotensin II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-22 | — | — | US | disclosed |