Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.66 |
| ▸ | TP53 | P04637 | 4/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10090752 | 0.86 | LMNA (0.76) | LMNAALDH1A1L3MBTL1SMN1; SMN2TP53 | |
| SCHEMBL19286329 | 0.85 | LMNA (0.71) | LMNAALDH1A1L3MBTL1SMN1; SMN2TP53 | |
| SCHEMBL880292 | 0.85 | LMNA (0.71) | LMNAALDH1A1L3MBTL1SMN1; SMN2TP53 | |
| SCHEMBL880309 | 0.85 | LMNA (0.71) | LMNAALDH1A1L3MBTL1SMN1; SMN2TP53 | |
| SCHEMBL852839 | 0.79 | KMT2A (1.00) | LMNAALDH1A1L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL880284 | 0.79 | TP53 (0.85) | LMNAALDH1A1L3MBTL1SMN1; SMN2TP53 | |
| SCHEMBL10090742 | 0.78 | TP53 (0.76) | LMNAALDH1A1L3MBTL1SMN1; SMN2TP53 | |
| SCHEMBL18522860 | 0.77 | SMN1; SMN2 (0.76) | LMNAALDH1A1SMN1; SMN2TP53MAPT | |
| SCHEMBL29433759 | 0.77 | SMN1; SMN2 (0.76) | LMNAALDH1A1SMN1; SMN2TP53MAPT | |
| SCHEMBL880278 | 0.76 | SMN1; SMN2 (0.73) | LMNAALDH1A1L3MBTL1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9744171-B2 | Positive allosteric modulators for melanocortin receptors | VANDERBILT UNIVERSITY (US) | 2017-08-29 | — | — | US | disclosed |
| US-20130289022-A1 | TETRAMERIC ALPHA-SYNUCLEIN AND USE THEREOF | BRANDEIS UNIVERSITY (US) | 2013-10-31 | — | — | US | disclosed |
| WO-2013134376-A1 | POSITIVE ALLOSTERIC MODULATORS FOR MELANOCORTIN RECEPTORS | VANDERBILT UNIVERSITY (US) | 2013-09-12 | — | — | WO | disclosed |
| EP-2433634-A2 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-03-28 | — | — | EP | disclosed |