Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13243088 | 0.92 | MEN1 (0.42) | MEN1KMT2ACYP2D6OGFRL1OPRM1 | |
| SCHEMBL853501 | 0.80 | MAPK1 (0.45) | MEN1KMT2ACYP2D6OGFRL1OPRM1 | |
| SCHEMBL21547917 | 0.78 | KMT2A (0.41) | MEN1KMT2ACYP2D6OPRM1OPRK1 | |
| SCHEMBL10269953 | 0.78 | KMT2A (0.46) | MEN1KMT2ACYP2D6OPRM1OPRK1 | |
| SCHEMBL12028780 | 0.76 | KMT2A (0.45) | MEN1KMT2ACYP2D6OPRM1OPRK1 | |
| SCHEMBL12345490 | 0.76 | KMT2A (0.45) | MEN1KMT2ACYP2D6OPRM1OPRK1 | |
| SCHEMBL880757 | 0.76 | KMT2A (0.45) | MEN1KMT2ACYP2D6OPRM1OPRK1 | |
| SCHEMBL23315939 | 0.74 | PHGDH (0.45) | MEN1KMT2A | |
| SCHEMBL17661306 | 0.69 | — | — | |
| SCHEMBL20641844 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433937-A1 | Substituted-quinoxaline-type-piperidine compounds and the uses thereof | Purdue Pharma LP (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-2433935-A1 | Substituted-quinoxaline-type-piperidine compounds and the uses thereof | Purdue Pharma LP (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-2433936-A1 | Substituted-quinoxaline-type-piperidine compounds and the uses thereof | Purdue Pharma LP (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2009027820-A2 | SUBSTITUTED-QUINOXALINE-TYPE-PIPERIDINE COMPOUNDS AND THE USES THEREOF | PURDUE PHARMA L.P. (DE) | 2009-03-05 | — | — | WO | disclosed |