Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.52 |
| ▸ | MLNR | O43193 | 1/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14502963 | 0.84 | CHRNB2 (0.57) | KCNH2CHRNB2CHRNA7CHRNA4CHRNA5 | |
| SCHEMBL22110284 | 0.84 | CHRNB2 (0.57) | KCNH2CHRNB2CHRNA7CHRNA4CHRNA5 | |
| Hydrochloric Acid SCHEMBL11447676 | 0.83 | CHRNB2 (0.60) | KCNH2CHRNB2CHRNA7CHRNA4CHRNA5 | |
| SCHEMBL7546127 | 0.81 | CHRNB2 (0.57) | CHRM3CHRM1CHRM2HRH3CHRNB2 | |
| SCHEMBL7546116 | 0.81 | CHRNB2 (0.57) | CHRM3CHRM1CHRM2HRH3CHRNB2 | |
| SCHEMBL22110352 | 0.81 | KDM4E (0.48) | CHRM3HRH3LTA4HSMN1; SMN2 | |
| SCHEMBL11448915 | 0.81 | SLC2A1 (0.58) | ADRA2AKCNH2SLC2A1 | |
| SCHEMBL9963995 | 0.80 | SLC18A2 (0.68) | ADRA2A | |
| SCHEMBL22110281 | 0.79 | SLC18A2 (0.43) | CHRM3CHRNB2CHRNA7CHRNA4CHRNA5 | |
| SCHEMBL7322832 | 0.79 | SLC2A1 (0.59) | KCNH2HRH3LTA4HSLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625507-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-07-23 | — | — | EP | disclosed |
| US-5621010-A | ANTIHYPERCHOLESTEROLEMIA AND ANTIATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-04-15 | — | — | US | disclosed |
| EP-0625507-A2 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1994-11-23 | — | — | EP | disclosed |