Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.37 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8802086 | 0.86 | AKR1B1 (0.61) | AKR1B1 | |
| SCHEMBL8803352 | 0.83 | AKR1B1 (0.60) | NPC1MITFTP53SMN1; SMN2LMNA | |
| SCHEMBL9777761 | 0.76 | AKR1B1 (0.61) | AKR1B1 | |
| SCHEMBL7531257 | 0.75 | NPC1 (0.61) | NPC1MITFTP53SMN1; SMN2LMNA | |
| SCHEMBL8803594 | 0.72 | AKR1B1 (0.77) | AKR1B1 | |
| SCHEMBL9378243 | 0.72 | AKR1B1 (0.58) | AKR1B1 | |
| SCHEMBL8803653 | 0.72 | AKR1B1 (0.58) | AKR1B1 | |
| SCHEMBL8803129 | 0.71 | AKR1B1 (0.56) | AKR1B1 | |
| SCHEMBL8802350 | 0.71 | AKR1B1 (0.56) | AKR1B1 | |
| SCHEMBL9589559 | 0.71 | AKR1B1 (0.55) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618917-B1 | 1'-AMINO-2- (BENZOTHIAZOLYL)METHYL]SPIRO ISOQUINOLINE-4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PROD (US) | 1997-03-26 | — | — | EP | disclosed |
| EP-0618917-A1 | 1'-AMINO-2- (BENZOTHIAZOLYL)METHYL]SPIRO ISOQUINOLINE-4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS. | AMERICAN HOME PROD (US) | 1994-10-12 | — | — | EP | disclosed |
| WO-1993011126-A1 | 1'-AMINO-2-[(BENZOTHIAZOLYL)METHYL]SPIRO [ISOQUINOLINE-4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-06-10 | — | — | WO | disclosed |
| WO-1993011126-A1 | 1'-AMINO-2-[(BENZOTHIAZOLYL)METHYL]SPIRO [ISOQUINOLINE-4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-06-10 | — | — | WO | disclosed |
| US-5189168-A | Useful for the prevention or treatment of complications associated with diabetes mellitus | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-02-23 | — | — | US | disclosed |
| US-5189168-A | Useful for the prevention or treatment of complications associated with diabetes mellitus | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-02-23 | — | — | US | disclosed |
| US-5189168-A | Useful for the prevention or treatment of complications associated with diabetes mellitus | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-02-23 | — | — | US | disclosed |
| US-5189167-A | Useful for prevention or treatment of diabetes mellitus associated complications | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-02-23 | — | — | US | disclosed |
| US-5189167-A | Useful for prevention or treatment of diabetes mellitus associated complications | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-02-23 | — | — | US | disclosed |