Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.58 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.53 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.53 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.53 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.53 |
| ▸ | FASN | P49327 | 1/20 | 0.51 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.49 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.49 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPY1R | P25929 | 1/20 | 0.47 |
| ▸ | NPY2R | P49146 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10651016 | 0.87 | PARP1 (0.53) | PARP1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8136947 | 0.85 | PARP1 (0.55) | PARP1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8000855 | 0.84 | PARP1 (0.67) | PARP1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL5309020 | 0.83 | SERPINE1 (0.50) | PARP1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL5334737 | 0.81 | KDM5A (0.58) | PARP1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8785378 | 0.78 | FASN (0.81) | PARP1FASNDAOGRIN2DGRIN3B | |
| SCHEMBL10650769 | 0.78 | PARP1 (0.46) | PARP1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL11107841 | 0.78 | KDM4E (0.50) | PARP1FASNMEN1ALDH1A1POLB | |
| SCHEMBL8000790 | 0.77 | PARP1 (0.57) | PARP1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8139112 | 0.77 | MEN1 (0.70) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760819-A1 | TRICYCLIC DICARBONYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-12 | — | — | EP | disclosed |
| WO-1995032205-A1 | TRICYCLIC DICARBONYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1995-11-30 | — | — | WO | disclosed |