Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8806628 | 0.80 | OPRM1 (0.59) | ABCG2ABCB1NPC1RAB9AMAPT | |
| SCHEMBL8806633 | 0.80 | ABCG2 (0.56) | ABCG2ABCB1NPC1RAB9AMAPT | |
| SCHEMBL8808583 | 0.77 | CA12 (0.55) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL8808191 | 0.76 | MAPT (0.62) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL8809583 | 0.75 | MAPT (0.40) | ABCG2ABCB1NPC1RAB9AMAPT | |
| SCHEMBL8809325 | 0.75 | MEN1 (0.58) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL8808107 | 0.74 | MAPT (0.39) | ABCG2ABCB1NPC1RAB9AMAPT | |
| SCHEMBL8806668 | 0.74 | ABCG2 (0.89) | ABCG2ABCB1 | |
| SCHEMBL25346020 | 0.73 | ABCB1 (0.57) | ABCG2ABCB1NPC1RAB9AMAPT | |
| SCHEMBL8807078 | 0.73 | MAPT (0.46) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |