Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.78 |
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | LTA4H | P09960 | 2/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.53 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714917 | 0.92 | MAOB (0.68) | MAOBNPC1RAB9ALTA4HFFAR1 | |
| SCHEMBL7425998 | 0.89 | MAOB (0.58) | MAOBNPC1RAB9ALTA4HFFAR1 | |
| SCHEMBL403151 | 0.88 | MAOB (1.00) | MAOBARRAB9AMAOABCHE | |
| SCHEMBL7311874 | 0.85 | MAOB (0.86) | MAOBARRAB9ALTA4HEPHX2 | |
| SCHEMBL8618909 | 0.85 | MAOB (0.85) | MAOBARNPC1RAB9AFFAR1 | |
| SCHEMBL7302933 | 0.83 | MAOB (0.66) | MAOBNPC1RAB9AFFAR1MAOA | |
| SCHEMBL7372943 | 0.83 | MAOB (0.89) | MAOBARRAB9AMAOABCHE | |
| SCHEMBL28961976 | 0.83 | MAOB (0.89) | MAOBARRAB9AFFAR1FFAR4 | |
| SCHEMBL18664184 | 0.83 | MAOB (0.81) | MAOBARRAB9AMAOA | |
| SCHEMBL29741480 | 0.83 | MAOB (0.81) | MAOBARRAB9AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533781-B1 | 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVES AND ANALOGS AS HYPOGLYCEMIC AGENTS | PFIZER (US) | 1997-02-26 | — | — | EP | disclosed |
| US-5438074-A | 3-aryl-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents | PFIZER INC. (US) | 1995-08-01 | — | — | US | disclosed |
| US-5306726-A | 3-aryl-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents | PFIZER INC. (US) | 1994-04-26 | — | — | US | disclosed |
| US-5232945-A | 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives | PFIZER INC. (US) | 1993-08-03 | — | — | US | disclosed |
| EP-0533781-A1 | 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVES AND ANALOGS AS HYPOGLYCEMIC AGENTS. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991019702-A1 | 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVES AND ANALOGS AS HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1991-12-26 | — | — | WO | disclosed |