SCHEMBL403151

SCHEMBL403151

N#Cc1ccc(OCc2ccccc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 5/20 1.00
AR P10275 1/20 0.64
LMNA P02545 1/20 0.62
CYP1A2 P05177 1/20 0.62
PTGS1 P23219 1/20 0.62
SLC6A2 P23975 1/20 0.62
CYP2C19 P33261 1/20 0.62
PTGS2 P35354 1/20 0.62
SLC6A3 Q01959 1/20 0.62
HIF1A Q16665 1/20 0.62
HDAC6 Q9UBN7 1/20 0.62
RAB9A P51151 2/20 0.60
GAA P10253 1/20 0.60
MAPT P10636 1/20 0.60
MAOA P21397 1/20 0.60
SMN1; SMN2 Q16637 1/20 0.60
L3MBTL1 Q9Y468 1/20 0.60
BCHE P06276 1/20 0.56
CYP19A1 P11511 1/20 0.56
NR4A1 P22736 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7372943 0.94 MAOB (0.89) MAOBARLMNACYP1A2PTGS1
SCHEMBL28961976 0.94 MAOB (0.89) MAOBARLMNACYP1A2PTGS1
SCHEMBL7311874 0.93 MAOB (0.86) MAOBARLMNACYP1A2PTGS1
SCHEMBL8618909 0.92 MAOB (0.85) MAOBARLMNACYP1A2PTGS1
SCHEMBL30354424 0.90 MAOB (0.81) MAOBARLMNACYP1A2PTGS1
SCHEMBL29741480 0.90 MAOB (0.81) MAOBARRAB9AMAOACYP19A1
SCHEMBL18664184 0.90 MAOB (0.81) MAOBARRAB9AMAOACYP19A1
SCHEMBL20240306 0.89 MAOB (0.80) MAOBARRAB9ABCHECYP19A1
SCHEMBL1249162 0.89 MAOB (0.80) MAOBARRAB9ABCHECYP19A1
SCHEMBL8806782 0.88 MAOB (0.78) MAOBARRAB9AMAOABCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 294 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113861069-B Preparation method of nitrile compound 陕西国际商贸学院 2023-06-16 CN claimed
EP-1055658-B1 Process for cis-1- 2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]ethyl pyrrolidine PFIZER PROD INC (US) 2003-03-12 EP claimed
US-20020042524-A1 Process for cis-1{2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy] ethyl}pyrrolidine CHIU CHARLES K F (US) 2002-04-11 US claimed
US-6323345-B1 BROMINATING 2-BROMO-5-METHOXY-TOLUENE TO PROVIDE 1-BROMO-2-BROMOMETHYL-4-METHOXYBENZENE; DECARBOXYLATION, REACTING WITH ETHYLENE GLYCOL; REACTING WITH N-BUTYL LITHIUM AND 4-BENZYLOXY BENZONITRILE; HYDROLYSIS, HYDROGENATION PFIZER INC. 2001-11-27 US claimed
CN-1280128-A Process for the preparation of cis-1- { 2- [ 4- (6-methoxy-2-phenyl-1, 2,3, 4-tetrahydronaphthalen-1-yl) phenoxy ] ethyl } pyrrolidine PFIZER PRODUCT CO (US) 2001-01-17 CN claimed
EP-1055658-A2 Process for cis-1- 2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]ethyl pyrrolidine Pfizer Products Inc. (US) 2000-11-29 EP claimed
JP-1316367-A None JP disclosed
US-20250388542-A1 ANALOGUES OF PENTAMIDINE AND USES THEREFOR AURANSA INC. (US) 2025-12-25 US disclosed
EP-4559918-A2 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS Genzyme Corporation (US) 2025-05-28 EP disclosed
EP-3673906-B1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GENZYME CORP (US) 2025-05-14 EP disclosed
CN-115515685-B EIF4E inhibitors and uses thereof 皮克医疗公司 2025-04-08 CN disclosed
US-20250025443-A1 COMPOUNDS AND METHODS FOR TREATING CORONA VIRUSES Clear Creek Bio, Inc. (US) 2025-01-23 US disclosed
US-12157731-B2 EIF4E inhibitors and uses thereof PIC Therapeutics, Inc. (US) 2024-12-03 US disclosed
US-4973425-A ELECTROOPTICS DAISO CO., LTD. (JP) 1990-11-27 US disclosed
US-4909957-A Containing lactone ring structure DAISO CO., LTD. (JP) 1990-03-20 US disclosed
EP-0355830-A2 Liquid crystal composition and use thereof DAISO CO., LTD. (JP) 1990-02-28 EP disclosed
JP-H01316367-A LIQUID CRYSTAL SUBSTANCE HAVING HETEROCYCLIC SKELETON SHOWA SHELL SEKIYU KK 1989-12-21 JP disclosed
EP-0328026-A1 Substituted pyrroles F. HOFFMANN-LA ROCHE AG (CH) 1989-08-16 EP disclosed
EP-0306919-A2 Liquid crystalline compounds and process for production thereof DAISO CO., LTD. (JP) 1989-03-15 EP disclosed
US-4098816-A HYPOGLYCEMIC AGENTS AND ANTILIPEMIC AGENTS BEECHAM GROUP LIMITED (GB) 1978-07-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250388542-A1 ANALOGUES OF PENTAMIDINE AND USES THEREFOR MALT1, SLC38A7, SLC7A1 MAOB 4499/4885AR 546/4885LMNA 3402/4885
US-20020042524-A1 Process for cis-1{2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy] ethyl}pyrrolidine P4HA1, PAH, DNM1 MAOB 3174/4885AR 1299/4885LMNA 1208/4885
US-12157731-B2 EIF4E inhibitors and uses thereof EIF4E, EIF4EBP1, EIF4A1 MAOB 4402/4885AR 3889/4885LMNA 2647/4885
US-20250025443-A1 COMPOUNDS AND METHODS FOR TREATING CORONA VIRUSES ACE, PREP, PEPD MAOB 693/4885AR 3951/4885LMNA 627/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.