Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 8/20 | 0.34 |
| ▸ | KDR | P35968 | 7/20 | 0.34 |
| ▸ | KIF5B | P33176 | 6/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | GAK | O14976 | 1/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20355005 | 0.84 | JAK3 (0.35) | EGFRCSF1RKDM4EMAPTIRAK4 | |
| SCHEMBL25552038 | 0.84 | EGFR (0.40) | EGFRCSF1RMAPTIRAK4RET | |
| SCHEMBL16016669 | 0.81 | RET (0.47) | EGFRCSF1RIRAK4RETKDR | |
| SCHEMBL25873553 | 0.80 | GABRP (0.41) | KDM4ESMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL25873554 | 0.80 | SMN1; SMN2 (0.36) | KDM4EMAPTKDRSMN1; SMN2HTT | |
| SCHEMBL14579634 | 0.77 | GAA (0.42) | EGFRMAPTALDH1A1 | |
| SCHEMBL12703881 | 0.77 | EGFR (0.44) | EGFRCSF1RKDM4EMAPTIRAK4 | |
| SCHEMBL18013039 | 0.77 | EGFR (0.42) | EGFRIRAK4RETKDRKIF5B | |
| SCHEMBL15890160 | 0.76 | GAK (0.39) | GAKRIPK2 | |
| SCHEMBL1012225 | 0.75 | HTT (0.50) | KDM4EMAPTIRAK4SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0782570-A1 | SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009294-A1 | SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |