Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 3/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 4/20 | 0.45 |
| ▸ | CTSV | O60911 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | NT5E | P21589 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20817543 | 0.78 | ICMT (0.76) | ICMTSCN9A | |
| SCHEMBL30618813 | 0.78 | ICMT (0.76) | ICMTSCN9A | |
| SCHEMBL13035808 | 0.77 | NT5E (0.50) | ICMTNT5E | |
| SCHEMBL980384 | 0.76 | PIK3CD (0.50) | ICMTNT5E | |
| SCHEMBL28718890 | 0.76 | PIK3CD (0.43) | ICMTUSP30CTSVCTSLCTSB | |
| SCHEMBL2658997 | 0.76 | CTSA (0.44) | ICMTUSP30NT5E | |
| SCHEMBL16404618 | 0.76 | KDM5A (0.48) | ICMTEGLN2NOTUMUSP30GRM5 | |
| SCHEMBL20817541 | 0.76 | NT5E (0.63) | NT5E | |
| SCHEMBL30797840 | 0.76 | NT5E (0.63) | NT5E | |
| SCHEMBL11473783 | 0.75 | EGLN2 (0.68) | CLK4EGLN2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784612-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | disclosed |