Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807469 | 1.00 | HTR1A (0.47) | HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL8809796 | 0.84 | HTR1A (0.42) | HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL8809800 | 0.84 | HTR1A (0.42) | HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL8807616 | 0.82 | HTR1A (0.64) | HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL8807619 | 0.82 | HTR1A (0.64) | HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL8808260 | 0.80 | HTR1A (0.56) | HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL8808266 | 0.80 | HTR1A (0.56) | HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL8812201 | 0.76 | HTR1A (0.65) | HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL7432539 | 0.70 | HTR1A (0.65) | HTR1A | |
| SCHEMBL7432544 | 0.70 | HTR1A (0.65) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0586525-B1 | CARBOXAMIDO-(1,2N)-CARBOCYCLIC-2-AMINOTETRALIN DERIVATIVES | UPJOHN CO (US) | 1997-04-16 | — | — | EP | claimed |
| EP-0586525-B1 | CARBOXAMIDO-(1,2N)-CARBOCYCLIC-2-AMINOTETRALIN DERIVATIVES | UPJOHN CO (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5486611-A | CENTRAL NERVOUS SYSTEM | THE UPJOHN COMPANY (US) | 1996-01-23 | — | — | US | disclosed |