Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | TACR2 | P21452 | 3/20 | 0.49 |
| ▸ | TACR1 | P25103 | 3/20 | 0.49 |
| ▸ | TACR3 | P29371 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956501 | 0.89 | HRH1 (0.56) | HRH1ALDH1A1CYP1A2TACR2TACR1 | |
| SCHEMBL8356058 | 0.87 | HRH1 (0.48) | HRH1ALDH1A1CYP1A2TACR2TACR1 | |
| SCHEMBL6993383 | 0.86 | TACR2 (0.61) | HRH1ALDH1A1CYP1A2TACR2TACR1 | |
| SCHEMBL6997998 | 0.84 | TACR2 (0.53) | HRH1TACR2TACR1TACR3 | |
| SCHEMBL6996252 | 0.84 | HRH1 (0.53) | HRH1TACR2TACR1TACR3 | |
| SCHEMBL8356231 | 0.82 | TACR2 (0.75) | HRH1TACR2TACR1TACR3 | |
| SCHEMBL6991465 | 0.82 | CDK5 (0.54) | HRH1ALDH1A1CYP1A2TACR2TACR1 | |
| SCHEMBL6997426 | 0.81 | TACR2 (0.58) | HRH1TACR2TACR1TACR3 | |
| SCHEMBL6996300 | 0.81 | ALDH1A1 (0.58) | HRH1ALDH1A1TACR2TACR1TACR3 | |
| SCHEMBL6990594 | 0.81 | TACR2 (0.56) | HRH1TACR2TACR1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696280-B1 | SUBSTITUTED PYRROLIDIN-3-YL-ALKYL-PIPERIDINES USEFUL AS TACHYKININ ANTAGONISTS | MERRELL PHARMA INC (US) | 1997-09-24 | — | — | EP | disclosed |
| US-5661160-A | ADMINISTERING AN ANTITUSSIVE AGENT FOR TREATING COUGH; TACHYKININ ANTAGONISM, SUBSTANCE P AND NEUROKININ A ANTAGONISM | MERRELL PHARMACEUTICALS INC. (US) | 1997-08-26 | — | — | US | disclosed |
| US-5648366-A | TACHYKININ ANTAGONISTS USEFUL IN TREATING ASTHMA | MERRELL PHARMACEUTICALS INC. (US) | 1997-07-15 | — | — | US | disclosed |
| US-5635510-A | TACHYKININ (ESPECIALLY SUBSTANCE P AND NEUROKININ A) ANTAGONISTS; ANTIINFLAMMATORY AGENTS, ANALGESICS; NERVOUS SYSTEM DISORDERS; BRONCHODILATOR AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1997-06-03 | — | — | US | disclosed |
| EP-0696280-A1 | SUBSTITUTED PYRROLIDIN-3-YL-ALKYL-PIPERIDINES USEFUL AS TACHYKININ ANTAGONISTS | MERRELL DOW PHARMA (US) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994026735-A1 | SUBSTITUTED PYRROLIDIN-3-YL-ALKYL-PIPERIDINES USEFUL AS TACHYKININ ANTAGONISTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-11-24 | — | — | WO | disclosed |