Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 5/20 | 0.61 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.61 |
| ▸ | GRIK3 | Q13003 | 5/20 | 0.61 |
| ▸ | GRIK4 | Q16099 | 5/20 | 0.61 |
| ▸ | GRIK5 | Q16478 | 5/20 | 0.61 |
| ▸ | GRIA1 | P42261 | 5/20 | 0.61 |
| ▸ | GRIA2 | P42262 | 5/20 | 0.61 |
| ▸ | GRIA3 | P42263 | 5/20 | 0.61 |
| ▸ | GRIA4 | P48058 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | GRM6 | O15303 | 1/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3691418 | 0.96 | KMT2A (0.65) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL3673298 | 0.85 | GRIK1 (0.57) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL3668211 | 0.84 | GRIK1 (0.59) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL3680472 | 0.83 | GRIK1 (0.55) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL9396484 | 0.83 | GRIA1 (0.46) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL3688250 | 0.82 | GRIA1 (0.54) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| Bicarbonate SCHEMBL8806909 | 0.82 | SIRT2 (0.47) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL3680432 | 0.80 | KMT2A (0.56) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL3683015 | 0.80 | GRIA1 (0.58) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| Bicarbonate SCHEMBL8805354 | 0.79 | CDK2 (0.41) | GRIK1GRIK2GRIK3GRIK4GRIK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696289-B1 | BENZO[F]QUINOXALINDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS | SCHERING AG (DE) | 1997-03-12 | — | — | EP | claimed |
| EP-0696289-B1 | BENZO[F]QUINOXALINDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS | SCHERING AG (DE) | 1997-03-12 | — | — | EP | disclosed |
| WO-1994025470-A1 | BENZO[F]QUINOXALINDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-11-10 | — | — | WO | disclosed |