Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 9/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.42 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.42 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.42 |
| ▸ | GRIK4 | Q16099 | 3/20 | 0.42 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8807930 | 0.82 | GRIK1 (0.61) | PARP1GRIK1GRIK2GRIK3GRIK4 | |
| SCHEMBL9396484 | 0.81 | GRIA1 (0.46) | SIRT2PARP1GRIK1GRIK2GRIK3 | |
| SCHEMBL8621659 | 0.81 | SIRT2 (0.43) | SIRT2PARP1GRIK1GRIK2GRIK3 | |
| SCHEMBL8618891 | 0.81 | GRIK1 (0.57) | SIRT2GRIK1GRIK2GRIK3GRIK4 | |
| Bicarbonate SCHEMBL8807164 | 0.81 | SIRT2 (0.47) | SIRT2PARP1GRIK1GRIK2GRIK3 | |
| SCHEMBL8805561 | 0.79 | SIRT2 (0.41) | SIRT2GRIK1GRIK2GRIK3GRIK4 | |
| SCHEMBL8621742 | 0.76 | SIRT2 (0.43) | SIRT2PARP1GRIK1GRIK2GRIK3 | |
| SCHEMBL3691418 | 0.76 | KMT2A (0.65) | SIRT2PARP1GRIK1GRIK2GRIK3 | |
| SCHEMBL9749640 | 0.76 | MEN1 (0.43) | SIRT2GRIK1GRIK2GRIK3GRIK4 | |
| SCHEMBL8619770 | 0.75 | GRIA1 (0.44) | SIRT2GRIK1GRIK2GRIK3GRIK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696289-B1 | BENZO[F]QUINOXALINDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS | SCHERING AG (DE) | 1997-03-12 | — | — | EP | claimed |
| EP-0696289-B1 | BENZO[F]QUINOXALINDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS | SCHERING AG (DE) | 1997-03-12 | — | — | EP | disclosed |
| WO-1994025470-A1 | BENZO[F]QUINOXALINDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-11-10 | — | — | WO | disclosed |