Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.76 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.60 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 3/20 | 0.51 |
| ▸ | BCHE | P06276 | 2/20 | 0.50 |
| ▸ | BACE1 | P56817 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11615671 | 0.90 | POLB (0.93) | POLBHRH3FOXM1LMNAALOX12 | |
| SCHEMBL5863714 | 0.90 | POLB (0.93) | POLBHRH3FOXM1LMNAALOX12 | |
| SCHEMBL11112228 | 0.88 | POLB (0.96) | POLBHRH3LMNAALOX12EPHX1 | |
| SCHEMBL9056626 | 0.86 | HRH3 (0.62) | POLBHRH3LMNAALOX12EPHX1 | |
| SCHEMBL8497509 | 0.86 | HRH3 (0.62) | POLBHRH3LMNAALOX12EPHX1 | |
| SCHEMBL8809145 | 0.85 | POLB (0.83) | POLBHRH3LMNAALOX12EPHX1 | |
| SCHEMBL31083251 | 0.85 | POLB (0.89) | POLBHRH3LMNAALOX12EPHX1 | |
| SCHEMBL8812297 | 0.84 | HRH3 (0.60) | POLBHRH3ACHEBCHEBACE1 | |
| SCHEMBL8810030 | 0.84 | HRH3 (0.60) | POLBHRH3LMNAACHEBCHE | |
| SCHEMBL8494718 | 0.84 | HRH3 (0.59) | POLBHRH3LMNAALOX12EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784612-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | disclosed |