Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.77 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8812217 | 0.97 | ADORA1 (0.73) | ADORA1HTTHSD17B10CYP1A2ALDH1A1 | |
| SCHEMBL9007316 | 0.96 | ADORA1 (0.72) | ADORA1HTTHSD17B10CYP1A2ALDH1A1 | |
| SCHEMBL19829272 | 0.88 | ADORA1 (0.86) | ADORA1HTTHSD17B10EGFRMAPK1 | |
| SCHEMBL2641189 | 0.87 | ADORA1 (1.00) | ADORA1HTTHSD17B10MAPK1KDM4E | |
| SCHEMBL7290695 | 0.86 | ADORA1 (0.62) | ADORA1HTTHSD17B10CYP1A2ALDH1A1 | |
| SCHEMBL8808083 | 0.85 | ADORA1 (0.73) | ADORA1HTTHSD17B10CYP1A2ALDH1A1 | |
| SCHEMBL8807647 | 0.84 | ADORA1 (0.94) | ADORA1HTTHSD17B10MAPK1KDM4E | |
| SCHEMBL7292843 | 0.84 | ADORA1 (0.72) | ADORA1HTTHSD17B10CYP1A2EGFR | |
| SCHEMBL7290693 | 0.84 | ADORA1 (0.64) | ADORA1HTTHSD17B10CYP1A2ALDH1A1 | |
| SCHEMBL8807266 | 0.83 | ADORA1 (0.88) | ADORA1HTTHSD17B10CYP1A2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0379979-B1 | Pyrazolopyridine compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1997-03-19 | — | — | EP | disclosed |
| US-5155114-A | Treating or preventing renal toxicity, nephrosis, nephritis | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| US-4985444-A | Pyrazolopyridine compound and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-01-15 | — | — | US | disclosed |
| EP-0379979-A1 | Pyrazolopyridine compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-01 | — | — | EP | disclosed |