Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 8/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL555279 | 0.78 | ATM (0.57) | ATMNPSR1PRMT5ARPARP1 | |
| SCHEMBL1032659 | 0.76 | PRMT5 (0.60) | ATMNPSR1PRMT5ARPARP1 | |
| SCHEMBL599352 | 0.74 | NPSR1 (0.57) | ATMNPSR1PRMT5ARPARP1 | |
| SCHEMBL16012918 | 0.74 | ATM (0.57) | ATMNPSR1PRMT5ARPARP1 | |
| SCHEMBL4060640 | 0.74 | ATM (0.57) | ATMNPSR1PRMT5ARPARP1 | |
| SCHEMBL765469 | 0.74 | ATM (0.57) | ATMNPSR1PRMT5ARPARP1 | |
| SCHEMBL9766383 | 0.74 | ATM (0.57) | ATMNPSR1PRMT5ARPARP1 | |
| SCHEMBL555280 | 0.74 | ATM (0.57) | ATMNPSR1PRMT5ARPARP1 | |
| SCHEMBL17571634 | 0.74 | ATM (0.52) | ATMNPSR1PRMT5ARPARP1 | |
| SCHEMBL1012344 | 0.73 | KDM4E (0.58) | KDM4EALDH1A1GAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539805-B1 | Phthalazines substituted on position 1 by an ether group and process for their preparation | ASTA MEDICA AG (DE) | 1997-09-03 | — | — | EP | disclosed |
| US-4239759-A | Morpholino containing compounds, compositions and use thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-12-16 | — | — | US | disclosed |
| US-4110447-A | Anti-inflammatory (halo-4-biphenylyl)-alkanolamines | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1978-08-29 | — | — | US | disclosed |