Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | THRA | P10827 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.47 |
| ▸ | CTSV | O60911 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4659661 | 0.90 | MAPT (0.51) | MAPTLMNATHRATHRBMEN1 | |
| SCHEMBL30466057 | 0.90 | MAPT (0.51) | MAPTLMNATHRATHRBMEN1 | |
| SCHEMBL2814768 | 0.84 | MAPT (0.50) | MAPTLMNAMEN1KMT2ACNR1 | |
| SCHEMBL9388459 | 0.83 | MEN1 (0.58) | MAPTLMNAMEN1KMT2ACYP19A1 | |
| SCHEMBL2877669 | 0.82 | MEN1 (0.65) | MAPTMEN1KMT2APOLBCNR1 | |
| SCHEMBL31071620 | 0.82 | MEN1 (0.65) | MAPTMEN1KMT2APOLBCNR1 | |
| SCHEMBL31440585 | 0.81 | MAPT (0.53) | MAPTLMNAMEN1KMT2ACNR1 | |
| SCHEMBL2419677 | 0.81 | MAPT (0.50) | MAPTLMNAMEN1KMT2ACNR1 | |
| SCHEMBL29831476 | 0.80 | PIN1 (0.50) | MAPTLMNAMEN1KMT2APOLB | |
| SCHEMBL18272220 | 0.79 | IDO1 (0.53) | MAPTLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0782570-A1 | SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009294-A1 | SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |