Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 5/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | ITGAL | P20701 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 13/20 | 0.36 |
| ▸ | CTSD | P07339 | 5/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2786604 | 1.00 | PGR (0.41) | PGRITGB2ICAM1ITGALBACE1 | |
| SCHEMBL3037435 | 0.91 | PGR (0.39) | PGRITGB2ICAM1ITGALBACE1 | |
| SCHEMBL2785053 | 0.88 | PGR (0.39) | PGRITGB2ICAM1ITGALBACE1 | |
| SCHEMBL3031400 | 0.88 | PGR (0.39) | PGRITGB2ICAM1ITGALBACE1 | |
| SCHEMBL3031304 | 0.86 | PGR (0.43) | PGRITGB2ICAM1ITGALBACE1 | |
| SCHEMBL8810824 | 0.83 | PGR (0.43) | PGRITGB2ICAM1ITGALBACE1 | |
| SCHEMBL3040098 | 0.83 | PGR (0.43) | PGRITGB2ICAM1ITGALBACE1 | |
| SCHEMBL3033345 | 0.83 | PGR (0.40) | PGRITGB2ICAM1ITGALBACE1 | |
| SCHEMBL2787392 | 0.83 | PGR (0.44) | PGRITGB2ICAM1ITGALBACE1 | |
| SCHEMBL3034171 | 0.83 | PGR (0.40) | PGRITGB2ICAM1ITGALBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209373-B1 | N-SUBSTITUTED OXINDOLINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK SHARP & DOHME (US) | 2012-05-23 | — | — | EP | disclosed |