Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808927 | 0.89 | POLB (0.51) | MEN1KMT2APOLBALDH1A1MAPT | |
| SCHEMBL8809638 | 0.80 | F10 (0.42) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL8807284 | 0.79 | ABCG2 (0.43) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL8809575 | 0.79 | F10 (0.41) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL8808106 | 0.78 | F10 (0.41) | MEN1KMT2APOLBALDH1A1MAPT | |
| SCHEMBL8808218 | 0.78 | ABCG2 (0.44) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL8807862 | 0.77 | ABCG2 (0.43) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL8807954 | 0.75 | F10 (0.43) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL8807354 | 0.75 | ABCG2 (0.40) | MEN1KMT2APOLBALDH1A1MAPT | |
| SCHEMBL8807055 | 0.75 | ABCG2 (0.43) | MEN1KMT2AALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |